光遗传学
溶瘤病毒
神经科学
癌症
癌细胞
计算生物学
生物
遗传增强
免疫系统
癌症研究
肿瘤细胞
基因
免疫学
遗传学
作者
Alexander Malogolovkin,Alexander D. Egorov,Alexander Karabelsky,Roman Ivanov,Vladislav V. Verkhusha
标识
DOI:10.1016/j.biotechadv.2022.108005
摘要
Gene and cell therapies are widely recognized as future cancer therapeutics but poor controllability limits their clinical applications. Optogenetics, the use of light-controlled proteins to precisely spatiotemporally regulate the activity of genes and cells, opens up new possibilities for cancer treatment. Light of specific wavelength can activate the immune response, oncolytic activity and modulate cell signaling in tumor cells non-invasively, in dosed manner, with tissue confined action and without side effects of conventional therapies. Here, we review optogenetic approaches in cancer research, their clinical potential and challenges of incorporating optogenetics in cancer therapy. We critically discuss beneficial combinations of optogenetic technologies with therapeutic nanobodies, T-cell activation and CAR-T cell approaches, genome editors and oncolytic viruses. We consider viral vectors and nanoparticles for delivering optogenetic payloads and activating light to tumors. Finally, we highlight herein the prospects for integrating optogenetics into immunotherapy as a novel, fast, reversible and safe approach to cancer treatment.
科研通智能强力驱动
Strongly Powered by AbleSci AI