Advances in C1-deuterated aldehyde synthesis

The recent surge in deuterated pharmaceutical compounds has created an urgent demand for new synthetic tools that allow facile access to D-containing building blocks. As one of the most predominant chemical entities in organic synthesis, aldehyde serves as a powerful linchpin in assembling structurally diverse molecular architectures. Recently, numerous efforts have been devoted to developing synthetic methods toward C1-deuterated aldehydes, which apparently broaden and streamline approaches toward versatile deuterated compounds. Herein, our aim is to offer a timely and comprehensive survey of this emerging topic. The overview is divided into four sections according to the synthesis tool utilized, with specific emphasis placed on the reaction design, mechanistic pathway, and resulting new synthetic paradigms.