The aim of this paper is to analyze the influence and differential weight of some specific psychological variables on adolescent antisocial behavior. A sample of 1,851 adolescents (49.92 % men and 50.08 % women) from the Autonomous Community of Madrid was assessed. Several stepwise regression analyses were conducted, considering three different age groups (14-15, 16 and 17-18 years), with the criterion variables and the results showed that the main psychological risk factors associated with antisocial behavior were variables linked to sensation seeking construct (impulsiveness, disinhibition, excitement seeking, etc.), while the protective factors identified were variables such as empathy and religious practices. The age groups were considered, keeping a design of optimum prevention programs with psychological character in mind.