谷胱甘肽
细胞内
胞浆
癌细胞
化学
细胞外
药物输送
聚合物囊泡
基因传递
毒品携带者
靶向给药
生物化学
细胞生物学
转染
生物
癌症
基因
两亲性
遗传学
有机化学
酶
聚合物
共聚物
作者
Ru Cheng,Feng Fang,Fenghua Meng,Chao Deng,Jan Feijén,Zhiyuan Zhong
标识
DOI:10.1016/j.jconrel.2011.01.030
摘要
The past couple of years have witnessed a tremendous progress in the development of glutathione-responsive nano-vehicles for targeted intracellular drug and gene delivery, as driven by the facts that (i) many therapeutics (e.g. anti-cancer drugs, photosensitizers, and anti-oxidants) and biotherapeutics (e.g. peptide and protein drugs, and siRNA) exert therapeutical effects only inside cells like the cytosol and cell nucleus, and (ii) several intracellular compartments such as cytosol, mitochondria, and cell nucleus contain a high concentration of glutathione (GSH) tripeptides (about 2–10 mM), which is 100 to 1000 times higher than that in the extracellular fluids and circulation (about 2–20 μM). Glutathione has been recognized as an ideal and ubiquitous internal stimulus for rapid destabilization of nano-carriers inside cells to accomplish efficient intracellular drug release. In this paper, we will review recent results on GSH-responsive nano-vehicles in particular micelles, nanoparticles, capsules, polymersomes, nanogels, dendritic and macromolecular drug conjugates, and nano-sized nucleic acid complexes for controlled delivery of anti-cancer drugs (e.g. doxorubicin and paclitaxel), photosensitizers, anti-oxidants, peptides, protein drugs, and nucleic acids (e.g. DNA, siRNA, and antisense oligodeoxynucleotide). The unique disulfide chemistry has enabled novel and versatile designs of multifunctional delivery systems addressing both intracellular and extracellular barriers. We are convinced that GSH-responsive nano-carrier systems have enormous potential in targeted cancer therapy.
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