Enantioselective [3+2]-cycloaddition of 2,3-disubstituted cyclobutenones: vicinal quaternary stereocenters construction and skeletal functionalization

An enantioselective [3+2]-cycloaddition of 2,3-disubstituted cyclobutenones and iminoesters was developed to synthesize an array of chiral azabicycles with up to three contiguous all-carbon quaternary centers.