体内
白蛋白
生物正交化学
化学
共轭体系
生物相容性材料
组合化学
血清白蛋白
催化作用
钌
反应性(心理学)
生物化学
生物物理学
有机化学
医学
生物医学工程
生物
病理
点击化学
生物技术
替代医学
聚合物
作者
K. Imai,Kyohei Muguruma,Akiko Nakamura,Yuriko Kusakari,Tsung‐Che Chang,Ambara R. Pradipta,Katsunori Tanaka
标识
DOI:10.1002/anie.202411225
摘要
Methods for producing drugs directly at the cancer site, particularly using bioorthogonal metal catalysts, are being explored to mitigate the side effects of therapy. Albumin‐based artificial metalloenzymes (ArMs) catalyze reactions in living mice while protecting the catalyst in the hydrophobic pocket. Here, we describe the in situ preparation and application of biocompatible tumor‐targeting ArMs using circulating albumin, which is abundant in the bloodstream. The ArM was formed using blood albumin through the intravenous injection of ruthenium conjugated with an albumin‐binding ligand; the tumor‐targeting unit was conjugated to the ArM using its catalytic activity, and the ArM was transported to the cancer site. The delivered ArM catalyzed a second tagging reaction of the proapoptotic peptide on the cancer surface, successfully suppressing cancer proliferation. This approach, which efficiently leveraged the persisting reactivity twice in vivo, holds promise for future in vivo metal‐catalyzed drug synthesis utilizing endogenous albumin.
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