清晨好,您是今天最早来到科研通的研友!由于当前在线用户较少,发布求助请尽量完整地填写文献信息,科研通机器人24小时在线,伴您科研之路漫漫前行!

Cross-regional coordination of activity in the human brain during autobiographical self-referential processing

心理学 自传体记忆 认知心理学 人脑 神经科学 认知科学 沟通 认知
作者
James Stieger,Pedro Pinheiro‐Chagas,Ying Fang,Jian Li,Zoe Lusk,Claire Perry,Manesh Girn,Diego Contreras,Qi Chen,John R. Huguenard,R. Nathan Spreng,Brian L. Edlow,Anthony D. Wagner,Vivek Buch,Josef Parvizi
出处
期刊:Proceedings of the National Academy of Sciences of the United States of America [National Academy of Sciences]
卷期号:121 (32) 被引量:4
标识
DOI:10.1073/pnas.2316021121
摘要

For the human brain to operate, populations of neurons across anatomical structures must coordinate their activity within milliseconds. To date, our understanding of such interactions has remained limited. We recorded directly from the hippocampus (HPC), posteromedial cortex (PMC), ventromedial/orbital prefrontal cortex (OFC), and the anterior nuclei of the thalamus (ANT) during two experiments of autobiographical memory processing that are known from decades of neuroimaging work to coactivate these regions. In 31 patients implanted with intracranial electrodes, we found that the presentation of memory retrieval cues elicited a significant increase of low frequency (LF < 6 Hz) activity followed by cross-regional phase coherence of this LF activity before select populations of neurons within each of the four regions increased high-frequency (HF > 70 Hz) activity. The power of HF activity was modulated by memory content, and its onset followed a specific temporal order of ANT→HPC/PMC→OFC. Further, we probed cross-regional causal effective interactions with repeated electrical pulses and found that HPC stimulations cause the greatest increase in LF-phase coherence across all regions, whereas the stimulation of any region caused the greatest LF-phase coherence between that particular region and ANT. These observations support the role of the ANT in gating, and the HPC in synchronizing, the activity of cortical midline structures when humans retrieve self-relevant memories of their past. Our findings offer a fresh perspective, with high temporal fidelity, about the dynamic signaling and underlying causal connections among distant regions when the brain is actively involved in retrieving self-referential memories from the past.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
方俊驰完成签到,获得积分10
1秒前
10秒前
ceeray23发布了新的文献求助20
15秒前
研友_8y2G0L完成签到,获得积分10
15秒前
liwang9301完成签到,获得积分10
22秒前
37秒前
41秒前
lyj完成签到 ,获得积分10
48秒前
Xuancheng_SINH完成签到,获得积分10
1分钟前
郭俊秀完成签到 ,获得积分10
1分钟前
1分钟前
ChatGPT发布了新的文献求助10
1分钟前
披着羊皮的狼完成签到 ,获得积分10
1分钟前
隐形曼青应助科研通管家采纳,获得10
1分钟前
ceeray23发布了新的文献求助20
1分钟前
orixero应助ceeray23采纳,获得20
2分钟前
1233发布了新的文献求助10
2分钟前
ChatGPT发布了新的文献求助10
2分钟前
JG完成签到 ,获得积分10
2分钟前
jkaaa完成签到,获得积分10
2分钟前
1233完成签到,获得积分10
2分钟前
太清完成签到 ,获得积分10
2分钟前
2分钟前
ceeray23发布了新的文献求助20
2分钟前
cadcae完成签到,获得积分10
2分钟前
Eric800824完成签到 ,获得积分10
3分钟前
庚朝年完成签到 ,获得积分10
3分钟前
violetlishu完成签到 ,获得积分10
3分钟前
ceeray23发布了新的文献求助20
4分钟前
yingzaifeixiang完成签到 ,获得积分10
4分钟前
wodetaiyangLLL完成签到 ,获得积分10
4分钟前
称心如意完成签到 ,获得积分10
4分钟前
h41692011完成签到 ,获得积分10
5分钟前
dingding发布了新的文献求助10
5分钟前
今后应助dingding采纳,获得10
5分钟前
Jj7完成签到,获得积分10
5分钟前
6分钟前
6分钟前
6分钟前
6分钟前
高分求助中
The Mother of All Tableaux: Order, Equivalence, and Geometry in the Large-scale Structure of Optimality Theory 3000
A new approach to the extrapolation of accelerated life test data 1000
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
Indomethacinのヒトにおける経皮吸収 400
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
基于可调谐半导体激光吸收光谱技术泄漏气体检测系统的研究 350
Robot-supported joining of reinforcement textiles with one-sided sewing heads 320
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3990550
求助须知:如何正确求助?哪些是违规求助? 3532220
关于积分的说明 11256532
捐赠科研通 3271057
什么是DOI,文献DOI怎么找? 1805207
邀请新用户注册赠送积分活动 882302
科研通“疑难数据库(出版商)”最低求助积分说明 809234