普氏粪杆菌
某种肠道细菌
拟杆菌
阿克曼西亚
等温微量热法
疣状疣
微生物群
生物
拟杆菌
微生物联合体
微生物学
肠道菌群
16S核糖体RNA
细菌
粪便
生物化学
拟杆菌
生物信息学
微生物
遗传学
物理
量子力学
焓
作者
Anna Kattel,Valter Aro,Petri‐Jaan Lahtvee,Jekaterina Kazantseva,Arvi Jõers,Ranno Nahku,Isma Belouah
摘要
The gut microbiota significantly contributes to human health and well-being. The aim of this study was to evaluate the stability and resilience of a consortium composed of three next-generation probiotics (NGPs) candidates originally found in the human gut. The growth patterns of Akkermansia muciniphila, Bacteroides thetaiotaomicron, and Faecalibacterium prausnitzii were studied both individually and consortium. The growth kinetics of Akkermansia muciniphila (A. muciniphila), Bacteroides thetaiotaomicron (B. thetaiotaomicron), and Faecalibacterium prausnitzii (F. prausnitzii) were characterized both individually and in consortium using isothermal microcalorimetry and 16S ribosomal RNA next-generation sequencing. The consortium reached stability after three passages and demonstrated resilience to changes in its initial composition. The concentration of butyrate produced was nearly twice as high in the consortium compared to the monoculture of F. prausnitzii. The experimental conditions and methodologies used in this article are a solid foundation for developing further complex consortia.
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