偷看
血管生成
骨愈合
再生(生物学)
嫁接
锶
骨移植
化学
炎症
材料科学
生物医学工程
细胞生物学
癌症研究
医学
牙科
外科
免疫学
复合材料
生物
聚合物
有机化学
作者
Liqiu Hu,Yongmei Ge,Zhe Cao,Ye Tian,Qili Sun,Zhen Li,Jing Ma,Yutong Wu,Ning Wang,Bin Tang
出处
期刊:Biomaterials advances
日期:2022-10-18
卷期号:143: 213160-213160
被引量:13
标识
DOI:10.1016/j.bioadv.2022.213160
摘要
Polyetheretherketone (PEEK) is a potential bone repair material because of its stable chemical and good mechanical properties. However, the biological inertness of PEEK limits its clinical application. Sr2+ has multi biological functions, including promoting bone formation and blood vessel regeneration and inhibiting inflammation. In this paper, PEEK was modified with Sr2+ with the purpose to construct PEEK bone graft material with triple functions of osteogenesis, angiogenesis, and anti-inflammatory. The results showed that Sr-modified PEEK could stably release Sr2+ for a long time in the PBS solution, and indeed could promote the proliferation and differentiation of osteoblasts, promote angiogenesis, and inhibit inflammation. Therefore, it is believed that this multifunctional PEEK with Sr2+ should show great promise for clinical applications in bone repair.
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