促炎细胞因子
骨关节炎
软骨细胞
白细胞介素2受体
II型胶原
免疫系统
炎症
过继性细胞移植
细胞因子
关节炎
免疫学
医学
化学
FOXP3型
软骨
癌症研究
药理学
T细胞
病理
解剖
替代医学
作者
Hee Su Sohn,Jeong Won Choi,JooYeon Jhun,Sung Pil Kwon,Mungyo Jung,Sangmin Yong,Hyun Sik Na,Jin–Hong Kim,Mi‐La Cho,Byung‐Soo Kim
出处
期刊:Science Advances
[American Association for the Advancement of Science (AAAS)]
日期:2022-11-23
卷期号:8 (47)
被引量:23
标识
DOI:10.1126/sciadv.abo5284
摘要
Local inflammation in the joint is considered to contribute to osteoarthritis (OA) progression. Here, we describe an immunomodulating nanoparticle for OA treatment. Intradermal injection of lipid nanoparticles (LNPs) loaded with type II collagen (Col II) and rapamycin (LNP-Col II-R) into OA mice effectively induced Col II–specific anti-inflammatory regulatory T cells, substantially increased anti-inflammatory cytokine expression, and reduced inflammatory immune cells and proinflammatory cytokine expression in the joints. Consequently, LNP-Col II-R injection inhibited chondrocyte apoptosis and cartilage matrix degradation and relieved pain, while injection of LNPs loaded with a control peptide and rapamycin did not induce these events. Adoptive transfer of CD4 + CD25 + T cells isolated from LNP-Col II-R–injected mice suggested that T regs induced by LNP-Col II-R injection were likely responsible for the therapeutic effects. Collectively, this study suggests nanoparticle-mediated immunomodulation in the joint as a simple and effective treatment for OA.
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