生物
表观遗传学
细胞生物学
T细胞
糖酵解
细胞
细胞分化
氧化磷酸化
祖细胞
线粒体
免疫系统
重编程
细胞代谢
新陈代谢
干细胞
免疫学
内分泌学
生物化学
基因
作者
Fēi Li,Huiling Liu,Dan Zhang,Ma Yin,Bingdong Zhu
出处
期刊:Immunology
[Wiley]
日期:2022-09-30
卷期号:167 (4): 482-494
被引量:9
摘要
The metabolic reprogramming during T cell activation and differentiation affects T cell fate and immune responses. Cell metabolism may serve as the driving force that induces epigenetic modifications, contributing to regulating T cell differentiation. Persistent pathogen infection leads to T cell exhaustion, which is composed of two main subsets and with distinct metabolic characteristics. The progenitor exhausted T cells utilize mitochondrial fatty acid oxidation (FAO) and oxidative phosphorylation (OXPHOS) for energy, while terminally exhausted T cells mainly rely on glycolytic metabolism with impaired glycolysis and OXPHOS. Here, we compiled the latest research on how T cell metabolism defines differentiation, focusing on T cell exhaustion during chronic infections. In addition, metabolic-related factors including antigen stimulation signals strength, cytokines and epigenetics affecting T cell exhaustion were also reviewed. Furthermore, the intervention strategies on metabolism and epigenetics to reverse T cell exhaustion were discussed in detail, which may contribute to achieving the goal of prevention and treatment of T cell exhaustion.
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