What are the current driving questions in immune repertoire research?

Adaptive immune receptors (AIRs: B cell receptors [BCRs] and/or T cell receptors [TCRs]) can recognize nearly any antigen by incredibly diverse AIR repertoires (AIRRs). AIRs are crucial to fighting infection but may inflict autoimmunity. Although current public AIR(R) sequence and structural databases are expanding rapidly in size, the majority of the stored data are antigen unlabeled. This leaves our knowledge of antigen specificity, one of the hallmark features of AIR mechanisms of action, scarce and hinders the precision manipulation and prediction of adaptive immunity.