柠檬黄单胞菌
柑橘溃疡病
黄单胞菌
病菌
生物
微生物学
分泌物
细菌
生物化学
遗传学
作者
Xin Wang,Lulu He,Yu‐Qing Zhang,Hao Tian,Min He,Alastair N. Herron,Zi‐Ning Cui
标识
DOI:10.1021/acs.jafc.3c05212
摘要
To find potential type III secretion system (T3SS) inhibitors against citrus canker caused by Xanthomonas citri subsp. citri (Xcc), a new series of 5-phenyl-2-furan carboxylic acid derivatives stitched with 2-mercapto-1,3,4-thiadiazole were designed and synthesized. Among the 30 compounds synthesized, 14 compounds significantly inhibited the promoter activity of a harpin gene hpa1. Eight of the 14 compounds did not affect the growth of Xcc, but significantly reduced the hypersensitive response (HR) of tobacco and decreased the pathogenicity of Xcc on citrus plants. Subsequent studies have demonstrated that these inhibitory molecules effectively suppress the T3SS of Xcc and significantly impair the pathogen's ability to subvert citrus immunity, resulting in a reduction in the level of disease progression. As a result, our work has identified a series of potentially attractive agents for the control of citrus canker.
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