化学
丙烯酰胺
色谱法
质谱法
分析物
串联质谱法
分辨率(逻辑)
等压法
高效液相色谱法
基质(化学分析)
再现性
分析化学(期刊)
有机化学
计算机科学
聚合物
物理
人工智能
共聚物
热力学
作者
Antonio Dario Troise,Andrea Scaloni
出处
期刊:Elsevier eBooks
[Elsevier]
日期:2024-01-01
卷期号:: 565-579
被引量:2
标识
DOI:10.1016/b978-0-323-99119-3.00014-x
摘要
The use of high-resolution mass spectrometry (HRMS) in combination with ultrahigh-pressure liquid chromatography (U-HPLC-HRMS) or direct analysis real time (DART-HRMS) defines new scenarios in the analysis of thermally induced toxicants, such as acrylamide. Several chemical factors contribute to the drawbacks related to the acrylamide quantitation: high polarity, low molecular weight, presence of isobaric compounds, and matrix effects. U-HPLC-HRMS offers some advantages as the possibility to resolve analytes of interest from the interferences, high reproducibility, high mass accuracy for elemental mass composition, unequivocal assignment of isotopes for parental ions and fragments. In parallel, DART approach can combine compound identification and chemometric tools as a specific declination of HRMS techniques. A general overview of the pros and cons related to acrylamide quantitation by HRMS is provided focusing on the relationship between predictive, indirect, and targeted MS analysis. Both techniques are compared to low-resolution tandem mass spectrometry to get more insights into the development of analytical strategies for acrylamide quantitation.
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