Impaired glymphatic system as evidenced by low diffusivity along perivascular spaces is associated with cerebral small vessel disease: a population-based study

血管周围间隙 人口 疾病 医学 淋巴系统 病理 脑脊液 环境卫生
作者
Yu Tian,Xueli Cai,Yijun Zhou,Aoming Jin,Suying Wang,Yingying Yang,Lerong Mei,Jing Jing,Shan Li,Xia Meng,Tiemin Wei,Tao Liu,Yongjun Wang,Yuesong Pan,Yilong Wang
出处
期刊:Stroke and vascular neurology [BMJ]
卷期号:8 (5): e002191-e002191 被引量:47
标识
DOI:10.1136/svn-2022-002191
摘要

This study aims to investigate the associations of glymphatic system with the presence, severity and neuroimaging phenotypes of cerebral small vessel disease (CSVD) in a community-based population.This report included 2219 community-dwelling people aged 50-75 years who participated in the PolyvasculaR Evaluation for Cognitive Impairment and vaScular Events cohort. The diffusivity along perivascular spaces based on diffusion tensor imaging (DTI-ALPS index) was measured to assess glymphatic pathway. The presence and severity of CSVD were estimated using a CSVD score (points from 0 to 4) and a modified CSVD score (points from 0 to 4), which were driven by 4 neuroimaging features of CSVD, including white matter hyperintensity (WMH), enlarged perivascular spaces (EPVS), lacunes, cerebral microbleeds. Brain atrophy (BA) was also evaluated. Binary or ordinal logistic regression analyses were carried out to investigate the relationships of DTI-ALPS index with CSVD.The mean age was 61.3 (SD 6.6) years, and 1019 (45.9%) participants were men. The average DTI-ALPS index was 1.67±0.14. Individuals in the first quartile (Q1) of the DTI-ALPS index had higher risks of the presence of CSVD (OR 1.77, 95% CI 1.33 to 2.35, p<0.001), modified presence of CSVD (odds ratio (OR) 1.80, 95% CI 1.38 to 2.34, p<0.001), total burden of CSVD (common OR (cOR) 1.89, 95% CI 1.43 to 2.49, p<0.001) and modified total burden of CSVD (cOR 1.95, 95% CI 1.51 to 2.50, p<0.001) compared with those in the fourth quartile (Q4). Additionally, individuals in Q1 of the DTI-ALPS index had increased risks of WMH burden, modified WMH burden, lacunes, basal ganglia-EPVS and BA (all p<0.05).A lower DTI-ALPS index underlay the presence, severity and typical neuroimaging markers of CSVD, implying that glymphatic impairment may interact with CSVD-related pathology in the general ageing population.NCT03178448.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
情怀应助不安乐菱采纳,获得10
1秒前
ccalvintan发布了新的文献求助10
1秒前
小陆发布了新的文献求助10
2秒前
完美世界应助牛牛采纳,获得10
2秒前
YL完成签到,获得积分10
3秒前
4秒前
4秒前
5秒前
JWW发布了新的文献求助10
6秒前
6秒前
ykk完成签到,获得积分10
8秒前
可爱deyi发布了新的文献求助10
8秒前
9秒前
NexusExplorer应助坚果采纳,获得10
9秒前
小辣椒发布了新的文献求助10
10秒前
axin发布了新的文献求助10
10秒前
小陆完成签到,获得积分10
10秒前
猪猪hero发布了新的文献求助10
10秒前
XY完成签到,获得积分10
11秒前
11秒前
小猫laila发布了新的文献求助10
11秒前
11秒前
微风发布了新的文献求助10
11秒前
打滚完成签到,获得积分10
12秒前
老弟需要帮助完成签到,获得积分10
12秒前
黒子发布了新的文献求助20
12秒前
13秒前
XY发布了新的文献求助10
14秒前
无花果应助洁净斑马采纳,获得10
14秒前
在水一方应助科研通管家采纳,获得10
14秒前
搜集达人应助科研通管家采纳,获得10
14秒前
大模型应助科研通管家采纳,获得10
14秒前
14秒前
15秒前
爆米花应助科研通管家采纳,获得10
15秒前
小二郎应助科研通管家采纳,获得10
15秒前
搜集达人应助科研通管家采纳,获得10
15秒前
15秒前
小蘑菇应助科研通管家采纳,获得10
15秒前
15秒前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
Picture Books with Same-sex Parented Families: Unintentional Censorship 500
Nucleophilic substitution in azasydnone-modified dinitroanisoles 500
不知道标题是什么 500
A Preliminary Study on Correlation Between Independent Components of Facial Thermal Images and Subjective Assessment of Chronic Stress 500
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 360
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3971441
求助须知:如何正确求助?哪些是违规求助? 3516161
关于积分的说明 11181180
捐赠科研通 3251322
什么是DOI,文献DOI怎么找? 1795788
邀请新用户注册赠送积分活动 876026
科研通“疑难数据库(出版商)”最低求助积分说明 805228