Abstract Baiget, E, Colomar, J, and Corbi, F. Joint-specific postactivation potentiation enhances serve velocity in young tennis players. J Strength Cond Res 37(4): 840–847, 2023—This study aimed (a) to analyze the influence of sport-specific postactivation potentiation (PAP) on serve velocity (SV) and serve accuracy (SA) in young tennis players, (b) to compare the PAP effects of 2 different conditioning activities (CA) on SV and SA, and (c) to explore if changes in SV would be related to tennis player's neuromuscular performance. Sixteen competition young tennis players performed 3 testing sessions in a randomized order. In the control session, subjects performed a warm-up protocol followed by the SV and SA tests. The experimental sessions involved 1 (shoulder internal rotation [SHIR]) or 2 (SHIR + shoulder flexion [SHF]) repetitions of a 5 second maximal voluntary isometric contraction (MVIC) executed before the SV and SA tests. Results showed a moderate significant ( p = 0.037) difference between SV at control session and following the SHIR + SHF CA protocol at minute 0 (3.4 ± 4.6%; 4.6 km·h −1 ; ES = 0.711). Serve accuracy did not differ between CA protocols and control session at any time point. No significant relations were found between force-time curve parameters and SV percent changes at different recovery times. Performing 2, short (5 seconds), upper-limb, tennis joint-specific MVIC seems to enhance SV without negatively affecting SA in young competition tennis players. On the contrary, performing one MVIC does not seem to obtain the same effects. Moreover, tennis players with improved neuromuscular performance do not seem to exhibit a better predisposition to postactivation performance enhancement.