Molecular mechanism of H2A/H2B dismantling from a partially unwrapped nucleosome by Nap1

During DNA transactions on chromatin such as transcription, replication, and DNA repair, RNA polymerases, replicative helicases, exonucleases, and so on inevitably collide with nucleosomes and unwrap nucleosomal DNA. Histones, components of a nucleosome, contain epigenetic information in the form of chemical modification, which regulates cell growth and fates. To maintain such information upon unwrapping, nucleosomes ahead of the DNA translocases are supposed to be temporarily disassembled. Histone chaperones are proteins modulating histone binding to DNA.