Tumor‐Microenvironment‐Responsive Cerium‐Enriched Copper Nanozyme with O2 Supply and Oxidative Stress Amplification for In Situ Disulfiram Chemotherapy and Chemodynamic Therapy Intensification

肿瘤微环境 氧化应激 二硫仑 活性氧 原位 化疗 化学 癌症研究 药理学 材料科学 生物化学 医学 冶金 肿瘤细胞 内科学 有机化学
作者
Jinyan Lin,Cailin Huang,Peiyuan Wang,Yueyang He,Qiang Luo,Xiaolong Liu,Yang Li
出处
期刊:Advanced Healthcare Materials [Wiley]
卷期号:13 (11): e2303955-e2303955 被引量:15
标识
DOI:10.1002/adhm.202303955
摘要

Traditional chemotherapy has faced tough challenges of systemic toxicity, hypoxia resistance, and inadequacy of monotherapy. Developing the tumor-specific O2-supply-enhanced chemotherapy without toxic drugs while combing other precise treatments can substantially improve therapeutic efficacy. Herein, a CeO2-enriched CuO nanozyme with O2 supply and oxidative stress amplification for tumor-specific disulfiram (DSF) chemotherapy and intensified chemodynamic therapy by synergistic in situ "nontoxicity-toxicity" activation is developed. Notably, CeO2 can not only act as a morphological "regulator," but also serve as a cascaded enzyme-mimetic catalyst via tumor-microenvironment-responsive cascaded-logical programmable valence conversion. Once internalized inside tumor cells, the nanozyme can be degraded by lysosomal acidity to release nontoxic DSF and Cu2+, which can trigger in situ "Cu2+-DSF" chelation, generating a highly toxic Cu(DTC)2 for in situ chemotherapy. Moreover, the enriched CeO2 with catalase-mimetic activity can decompose the endogenous H2O2 into O2, which can relieve the hypoxia to enhance the chemotherapeutic efficacy. Furthermore, the simultaneously generated Ce3+ can exert peroxidase-mimetic activity to catalyze H2O2 into hydroxyl radicals (•OH) for chemodynamic therapy. This Fenton-like chemistry is accompanied by the regeneration of Ce4+, which can deplete the intracellular overproduced GSH to amplify the oxidative stress. Therefore, this nanozyme can provide an alternative to precise cancer treatment.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
菜小瓜完成签到,获得积分10
1秒前
1秒前
有怀完成签到,获得积分10
1秒前
小小完成签到 ,获得积分10
1秒前
端庄安柏发布了新的文献求助10
1秒前
Hino完成签到 ,获得积分10
1秒前
今后应助开心采纳,获得10
1秒前
Camellia发布了新的文献求助10
2秒前
丘比特应助碧蓝的元绿采纳,获得30
2秒前
Yogita完成签到,获得积分10
3秒前
AA发布了新的文献求助10
5秒前
5秒前
maopf发布了新的文献求助10
6秒前
科研通AI6.2应助mm采纳,获得10
6秒前
zhang关注了科研通微信公众号
7秒前
7秒前
端庄安柏完成签到,获得积分20
7秒前
勤奋问儿发布了新的文献求助10
8秒前
yue应助LeMu采纳,获得10
9秒前
稳重的无招完成签到,获得积分10
9秒前
morlison完成签到,获得积分10
9秒前
zl完成签到,获得积分10
9秒前
科研通AI6.2应助fcyyc采纳,获得10
10秒前
11秒前
周y发布了新的文献求助10
11秒前
14秒前
14秒前
欧克发布了新的文献求助10
16秒前
优雅的老姆完成签到,获得积分10
17秒前
道阻且长发布了新的文献求助10
17秒前
Owen应助乔治的恐龙采纳,获得10
17秒前
正好完成签到,获得积分10
18秒前
衣兮完成签到,获得积分10
20秒前
20秒前
科研狗应助杨6239采纳,获得30
20秒前
20秒前
20秒前
21秒前
道阻且长完成签到,获得积分10
21秒前
怕黑的丹蝶完成签到,获得积分10
21秒前
高分求助中
(应助此贴封号)【重要!!请各用户(尤其是新用户)详细阅读】【科研通的精品贴汇总】 10000
HYDROLYSE ACIDE DE QUELQUES DIOXASPIROCYCLANES 1314
Essentials of Carbohydrate Chemistry and Biochemistry, 4th Edition 800
Navigating Normative Orders. Interdisciplinary Perspectives 800
1 Peter and Christ's Descent to the Dead in Its Early Christian Reception 700
A Psychological Understanding of Criticism and Mental Health 600
Organizational Behavior 510
热门求助领域 (近24小时)
化学 材料科学 医学 生物 纳米技术 工程类 有机化学 化学工程 生物化学 计算机科学 内科学 物理 复合材料 催化作用 细胞生物学 无机化学 光电子学 物理化学 电极 基因
热门帖子
关注 科研通微信公众号,转发送积分 7751508
求助须知:如何正确求助?哪些是违规求助? 9298835
关于积分的说明 20248682
捐赠科研通 7333543
什么是DOI,文献DOI怎么找? 3309868
关于科研通互助平台的介绍 2461450
邀请新用户注册赠送积分活动 2322529