The 730 nm picosecond titanium sapphire laser for treatment of café‐au‐lait macules in all skin types

医学 皮肤病科 胎记 外科 核医学
作者
Joan K. Fernandez,Emily L. Guo,Heather Richmond,Paul M. Friedman
出处
期刊:Lasers in Surgery and Medicine [Wiley]
标识
DOI:10.1002/lsm.23769
摘要

Abstract Objectives Café‐au‐lait macules (CALM) are benign birthmarks presenting as uniformly pigmented, well demarcated, brown patches that can be distressing to patients, especially when located in cosmetically sensitive areas. As with all pigmentary lesions in skin of color patients, CALMs have been particularly challenging to treat. Here we present the first case series characterizing treatment parameters and clinical outcomes utilizing the 730‐nm picosecond titanium sapphire laser for the treatment of CALMs. This device provides an additional safe and effective treatment option for these challenging cases. Methods We performed a retrospective review of patients treated at a single institution between April 2021 and December 2023. Clinical photographs were graded by 3 outside board‐certified dermatologists using a 5‐point visual analog scale. Results Fourteen patients (age range: 10 months–66 years, mean age: 27.4 years, Fitzpatrick skin types II–VI) were treated for CALM on the face (11) or body (3). On average, patients received 4.3 treatments, with treatment intervals ranging from 4 to 40 weeks. Treatment remains ongoing with the 730‐nm picosecond laser for eight patients. Overall, patients were rated to have a mean improvement of 26%–50%. Two patients (FST III and VI) achieved 100% clearance after 4‐5 treatment sessions. Our study included four patients whose CALM were of the smooth bordered “coast of California” subtype, three of whom had a mean improvement rating of only 1%–25%. The fourth patient had near complete resolution. Follow up for these patients has ranged from 6 weeks to 1.5 years. Of the patients treated, one patient experienced transient post‐inflammatory hyperpigmentation and another transient post‐inflammatory hypopigmentation, while a third patient experienced mild persistent guttate hypopigmentation. Three patients experienced partial recurrence indicating that maintenance treatments may be needed in some patients. Conclusion The 730‐nm picosecond titanium sapphire laser is a safe and efficacious treatment option, in the right morphologic setting, to improve the cosmetic appearance of CALMs in a wide range of ages and skin types. To our knowledge, this is the first reported treatment of CALMs with picosecond lasers in FST V and VI patients. Our study also supports prior studies which have found that CALM with smooth‐bordered “coast of California” morphology have a poor response to laser therapy as compared to those with jagged or ill‐defined bordered “coast of Maine” morphology.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
优雅映阳发布了新的文献求助10
1秒前
1秒前
默默冬瓜完成签到,获得积分10
2秒前
scsc发布了新的文献求助10
2秒前
lixm16完成签到,获得积分10
3秒前
妮妮发布了新的文献求助10
3秒前
fyj完成签到 ,获得积分20
4秒前
zyn发布了新的文献求助10
5秒前
NexusExplorer应助dilli采纳,获得10
5秒前
香蕉君达完成签到,获得积分10
5秒前
zxh656691发布了新的文献求助10
5秒前
默默冬瓜发布了新的文献求助10
6秒前
蓝荆完成签到,获得积分10
6秒前
英俊的铭应助CeciliaLee采纳,获得10
7秒前
7秒前
dong应助肯瑞恩哭哭采纳,获得10
7秒前
小火苗发布了新的文献求助10
8秒前
8秒前
蓝荆发布了新的文献求助10
8秒前
9秒前
10秒前
11秒前
fyj关注了科研通微信公众号
12秒前
12秒前
量子星尘发布了新的文献求助10
12秒前
深海学龙发布了新的文献求助10
13秒前
了一发布了新的文献求助10
13秒前
13秒前
13秒前
13秒前
澡雪发布了新的文献求助10
14秒前
HSA完成签到,获得积分10
17秒前
17秒前
Lord发布了新的文献求助10
17秒前
17秒前
17秒前
是希希啊a发布了新的文献求助10
17秒前
18秒前
郭九九呢完成签到,获得积分10
18秒前
MrRen发布了新的文献求助10
18秒前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
Picture Books with Same-sex Parented Families: Unintentional Censorship 700
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
Nucleophilic substitution in azasydnone-modified dinitroanisoles 500
不知道标题是什么 500
Indomethacinのヒトにおける経皮吸収 400
Effective Learning and Mental Wellbeing 400
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3976107
求助须知:如何正确求助?哪些是违规求助? 3520330
关于积分的说明 11202435
捐赠科研通 3256819
什么是DOI,文献DOI怎么找? 1798504
邀请新用户注册赠送积分活动 877642
科研通“疑难数据库(出版商)”最低求助积分说明 806496