This carer perspective article offers a unique insight into the lived experience of atopic dermatitis management in the setting of codiagnosed autism spectrum disorder (ASD). It delves into the profound effects of sensory reactivity in the setting of ASD, which poised a unique therapeutic challenge to management of this inflammatory skin disease. This article highlights the importance of an individualized approach and early initiation of systemic treatment when managing individuals with neuropsychiatric comorbidities.