节的
生物
原肠化
中胚层
神经外胚层
节点信号
形态发生剂
斑马鱼
细胞生物学
外胚层
形态发生
内胚层
胚胎
解剖
胚胎发生
遗传学
细胞分化
胚胎干细胞
基因
作者
Alyssa Alaniz Emig,Megan A Hansen,Sandra L. Grimm,Cristian Coarfa,Nathan D. Lord,Margot Williams
出处
期刊:Development
[The Company of Biologists]
日期:2024-12-09
摘要
Anteroposterior (AP) elongation of the vertebrate body plan is driven by convergence and extension (C&E) gastrulation movements in both the mesoderm and neuroectoderm, but how or whether molecular regulation of C&E differs between tissues remains an open question. Using a zebrafish explant model of AP axis extension, we show that C&E of the neuroectoderm and mesoderm can be uncoupled ex vivo, and that morphogenesis of individual tissues results from distinct morphogen signaling dynamics. Using precise temporal manipulation of BMP and Nodal signaling, we identify a critical developmental window during which high or low BMP/Nodal ratios induce neuroectoderm- or mesoderm-driven C&E, respectively. Increased BMP activity similarly enhances C&E specifically in the ectoderm of intact zebrafish gastrulae, highlighting the in vivo relevance of our findings. Together, these results demonstrate that temporal dynamics of BMP and Nodal morphogen signaling activate distinct morphogenetic programs governing C&E gastrulation movements within individual tissues.
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