线粒体DNA
生物
炎症体
核酸内切酶
线粒体
免疫
细胞生物学
DNA
遗传学
炎症
基因
免疫学
免疫系统
作者
Grace Lawrence,Caroline L. Holley,Kate Schroder
出处
期刊:Immunity
[Elsevier]
日期:2022-08-01
卷期号:55 (8): 1331-1333
被引量:8
标识
DOI:10.1016/j.immuni.2022.07.011
摘要
Oxidized mitochondrial DNA (ox-mtDNA) activates NLRP3 inflammasome signaling through an ill-defined mechanism. In this issue of Immunity, Xian et al. reveal FEN1 endonuclease cleaves ox-mtDNA into fragments that escape mitochondria, igniting NLRP3 and cGAS-STING signaling and inflammation.
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