间充质干细胞
纳米医学
癌细胞
癌症研究
向性
体内
细胞
材料科学
前药
纳米技术
癌症
医学
药理学
化学
免疫学
纳米颗粒
生物
生物技术
病理
病毒
内科学
生物化学
作者
Yizuo Song,Xin Shou,Bo Sheng,Jie Mei,Keqing Shi,Luoran Shang,Xueqiong Zhu
标识
DOI:10.1002/adhm.202202904
摘要
Abstract Nanoparticles (NPs)‐based drug carriers are effective in reducing systemic toxicity and drug resistance for chemotherapy, and an emerging trend focuses on integrating cell membranes with nanomedicines for tumor targeting. Mesenchymal stem cells (MSCs) are promising candidates due to their unique tropism toward cancer cells, yet the tumor‐tropic abilities can differ for MSCs sourced from different tissues. Here, a multichannel microfluidic chip to screen different sourced MSCs with the greatest tropism toward cervical cancer cells is developed. Based on this, the cell membranes from the chorionic plate‐derived MSC are isolated and membrane‐camouflaged platinum prodrug composite NPs for cervical cancer treatment are prepared. Results demonstrate that the composite NPs can effectively target tumor sites and have a therapeutic effect both in vitro and in vivo. It is believed that the present microfluidic platform is a powerful tool for cell screening and tumor‐on‐a‐chip studies, and the derived nanodelivery system represents the great value of cell membrane‐camouflaged nanomedicine for targeted cancer therapy.
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