光遗传学
糖尿病
医学
胰岛素
胰岛素抵抗
神经调节
神经科学
生物信息学
内科学
内分泌学
生物
刺激
作者
Xin Deng,Dandan Peng,Yuanfa Yao,Ke Huang,Jinling Wang,Zhihao Ma,Junfen Fu,Yingke Xu
标识
DOI:10.1111/1753-0407.13557
摘要
Abstract Diabetes mellitus (DM) is a common chronic disease affecting humans globally. It is characterized by abnormally elevated blood glucose levels due to the failure of insulin production or reduction of insulin sensitivity and functionality. Insulin and glucagon‐like peptide (GLP)‐1 replenishment or improvement of insulin resistance are the two major strategies to treat diabetes. Recently, optogenetics that uses genetically encoded light‐sensitive proteins to precisely control cell functions has been regarded as a novel therapeutic strategy for diabetes. Here, we summarize the latest development of optogenetics and its integration with synthetic biology approaches to produce light‐responsive cells for insulin/GLP‐1 production, amelioration of insulin resistance and neuromodulation of insulin secretion. In addition, we introduce the development of cell encapsulation and delivery methods and smart bioelectronic devices for the in vivo application of optogenetics‐based cell therapy in diabetes. The remaining challenges for optogenetics‐based cell therapy in the clinical translational study are also discussed. image
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