脂肪生成
肌内脂肪
过氧化物酶体增殖物激活受体γ
细胞生物学
受体
过氧化物酶体增殖物激活受体
生物
脂肪酸结合蛋白
增强子
基因
转录因子
内科学
内分泌学
脂肪组织
化学
生物化学
医学
作者
Ruirui Li,Ruirui Zhu,Xintong Yang,Ye Feng,Qin He,Haopeng Wang,Qingyou Liu,Deshun Shi,Jieping Huang
摘要
Abstract Intramuscular fat (IMF) is a crucial determinant of meat quality and is influenced by various regulatory factors. Despite the growing recognition of the important role of long noncoding RNAs (lncRNAs) in IMF deposition, the mechanisms underlying buffalo IMF deposition remain poorly understood. In this study, we identified and characterized a lncRNA, lncFABP4, which is transcribed from the antisense strand of fatty acid‐binding protein 4 ( FABP4 ). lncFABP4 inhibited cell proliferation in buffalo intramuscular preadipocytes. Moreover, lncFABP4 significantly increased intramuscular preadipocyte differentiation, as indicated by an increase in the expression of the adipogenic markers peroxisome proliferator‐activated receptor gamma ( PPARG ), CCAAT enhancer binding protein alpha ( C/EBPα ), and FABP4 . Mechanistically, lncFABP4 was found to have the potential to regulate downstream gene expression by participating in protein–protein interaction pathways. These findings contribute to further understanding of the intricate mechanisms through which lncRNAs modulate intramuscular adipogenesis in buffaloes.
科研通智能强力驱动
Strongly Powered by AbleSci AI