医学
子宫内膜癌
临床试验
免疫疗法
肿瘤科
疾病
癌症
靶向治疗
转化研究
内科学
生物信息学
病理
生物
作者
Alixe Salmon,Alizée Lebeau,Sylvie Streel,Adriane Dheur,Sophie Schoenen,Frédéric Goffin,Elodie Gonne,Frédéric Kridelka,Athanasios Kakkos,Christine Gennigens
标识
DOI:10.1016/j.ctrv.2024.102790
摘要
Until recently, patients diagnosed with locally advanced and metastatic endometrial cancer faced significant challenges in their treatment due to limited options and poor prognostic outcomes. The sequencing of tumors has been a major advancement in its management. It has led to The Cancer Genome Atlas classification currently used in clinical practice and the initiation of several clinical trials for innovative treatments targeting principally signaling pathways, immune checkpoints, DNA integrity, growth factors, hormonal signaling, and metabolism. Numerous clinical trials are investigating a combinatorial approach of these targeted therapies to counter tumoral resistance, cellular compensatory mechanisms, and tumor polyclonality. This review provides a comprehensive overview of historical, current, and promising therapies in advanced and metastatic endometrial cancer. It particularly highlights clinical research on targeted and hormonal therapies, but also immunotherapy, reflecting the evolving landscape of treatment modalities for this disease.
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