生物
减数分裂
染色质
遗传学
染色体分离
秀丽隐杆线虫
有丝分裂
细胞生物学
动细胞
粘蛋白
生殖系
体细胞
染色体
DNA
基因
作者
Qianyan Li,Sara Hariri,Aashna Calidas,Arshdeep Kaur,Erica Huey,JoAnne Engebrecht
出处
期刊:Genetics
[Oxford University Press]
日期:2024-06-17
卷期号:227 (4)
标识
DOI:10.1093/genetics/iyae102
摘要
53BP1 plays a crucial role in regulating DNA damage repair pathway choice and checkpoint signaling in somatic cells; however, its role in meiosis has remained enigmatic. In this study, we demonstrate that the Caenorhabditis elegans ortholog of 53BP1, HSR-9, associates with chromatin in both proliferating and meiotic germ cells. Notably, HSR-9 is enriched on the X chromosome pair in pachytene oogenic germ cells. HSR-9 is also present at kinetochores during both mitotic and meiotic divisions but does not appear to be essential for monitoring microtubule-kinetochore attachments or tension. Using cytological markers of different steps in recombinational repair, we found that HSR-9 influences the processing of a subset of meiotic double-stranded breaks into COSA-1-marked crossovers. Additionally, HSR-9 plays a role in meiotic X chromosome segregation under conditions where X chromosomes fail to pair, synapse, and recombine. Together, these results highlight that chromatin-associated HSR-9 has both conserved and unique functions in the regulation of meiotic chromosome behavior.
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