溶解度
化学
橙皮苷
柚皮素
溶解
色谱法
苯甲酸钠
水杨酸钠
水溶液
尿素
类黄酮
有机化学
生物化学
抗氧化剂
医学
替代医学
病理
作者
Bhawna Arora,Viney Lather,Mallikarjuna Bandrehalli Pathalingappa,Ramanpreet Walia
标识
DOI:10.1080/10286020.2024.2358831
摘要
The therapeutic potential of two important flavonoids, i.e. hesperidin and naringenin, remains unutilized due to pharmacokinetics issues, especially poor aqueous solubility. Hydrotropic solid dispersions with different agents like sodium salicylate, niacinamide, benzoic acid, and urea etc. can change the solubility profile of poorly soluble drugs. The current study investigated the potential of different hydrotropic agents in improving the solubility of both natural bioactives. The hydrotropic solid dispersion in 1:3 w/w drug: sodium salicylate ratio showed maximum solubility and dissolution amongst all the tested hydrotropes. This novel and economical approach could be explored for other poorly soluble pharmaceuticals.
科研通智能强力驱动
Strongly Powered by AbleSci AI