Evaluation of Background Parenchymal Enhancement and Histogram-Based Diffusion-Weighted Image in Determining the Molecular Subtype of Breast Cancer

医学 有效扩散系数 峰度 乳腺癌 直方图 磁共振成像 百分位 相关性 活检 乳房磁振造影 放射科 核医学 癌症 病理 内科学 人工智能 图像(数学) 乳腺摄影术 统计 计算机科学 数学 几何学
作者
Chao You,Yunyan Zhang,Yanqiong Chen,Xiaoxin Hu,HU Dan-ting,Jiong Wu,Yajia Gu,Weijun Peng
出处
期刊:Journal of Computer Assisted Tomography [Ovid Technologies (Wolters Kluwer)]
卷期号:45 (5): 711-716 被引量:2
标识
DOI:10.1097/rct.0000000000001239
摘要

Rationale and Objectives This study aimed to evaluate the value of background parenchymal enhancement (BPE) and diffusion-weighted image (DWI) histogram features in differentiating among different molecular subtypes of breast cancers and investigate the relationship between BPE and DWI features. Materials and Methods We prospectively enrolled 142 patients with breast cancer between January and November 2018. All patients underwent breast magnetic resonance imaging before core needle biopsy. The quantitative BPE from dynamic enhanced images and the first-order histogram features extracted from DWI were analyzed. Univariate analysis of variance was used to compare differences in DWI histogram features and BPE characteristics among different molecular subtypes. Spearman test was used to compare the correlation between these imaging indexes. Results A total of 142 patients had 142 lesions, including 17 cases of triple-negative breast cancer, 12 cases of luminal A type breast cancer, 39 cases of luminal B type breast cancer, and 74 cases of human epidermal growth factor receptor 2–positive breast cancer. The apparent diffusion coefficient (ADC) 95th percentile, ADC kurtosis, and BPE were significantly different among 4 subtype groups ( P < 0.05), especially between the triple-negative subtype and any other subtype ( P < 0.05 in pairwise comparisons). There was a weak but significant correlation between BPE and kurtosis of ADC ( r = −0.176, P = 0.036). Conclusions Diffusion-weighted image histogram features (95th percentile ADC value and kurtosis value of ADC) and BPE features were different in the 4 molecular subtypes of breast cancer, especially in the triple-negative breast cancer subtype. Background parenchymal enhancement was negatively correlated with the kurtosis value of ADC.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
wwqdd完成签到,获得积分10
2秒前
2秒前
king完成签到,获得积分10
3秒前
4秒前
香蕉觅云应助Bo采纳,获得10
4秒前
猴子魏应助迷路桃子采纳,获得20
4秒前
LLL发布了新的文献求助10
7秒前
Soleil发布了新的文献求助10
8秒前
zjw8456发布了新的文献求助10
8秒前
共享精神应助SU采纳,获得10
10秒前
YGTRECE发布了新的文献求助10
10秒前
英俊的铭应助HUAN采纳,获得10
11秒前
烟花应助mmm采纳,获得10
14秒前
17秒前
17秒前
我是老大应助LLL采纳,获得10
19秒前
灵巧白风给灵巧白风的求助进行了留言
20秒前
香蕉觅云应助大力爆米花采纳,获得10
21秒前
炙热逍遥发布了新的文献求助10
21秒前
堇妗完成签到,获得积分10
22秒前
23秒前
zjw8456完成签到,获得积分10
23秒前
26秒前
27秒前
28秒前
orixero应助hk1900采纳,获得10
28秒前
SU发布了新的文献求助10
28秒前
29秒前
30秒前
twk发布了新的文献求助10
31秒前
book发布了新的文献求助10
32秒前
Owen应助msl2023采纳,获得10
32秒前
四福祥发布了新的文献求助10
32秒前
32秒前
33秒前
ll发布了新的文献求助10
33秒前
期刊发布了新的文献求助10
33秒前
Bo发布了新的文献求助10
34秒前
34秒前
36秒前
高分求助中
Sustainability in Tides Chemistry 2800
The Young builders of New china : the visit of the delegation of the WFDY to the Chinese People's Republic 1000
юрские динозавры восточного забайкалья 800
English Wealden Fossils 700
Foreign Policy of the French Second Empire: A Bibliography 500
Chen Hansheng: China’s Last Romantic Revolutionary 500
XAFS for Everyone 500
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3145328
求助须知:如何正确求助?哪些是违规求助? 2796792
关于积分的说明 7821187
捐赠科研通 2453031
什么是DOI,文献DOI怎么找? 1305409
科研通“疑难数据库(出版商)”最低求助积分说明 627487
版权声明 601464