Evaluation of Background Parenchymal Enhancement and Histogram-Based Diffusion-Weighted Image in Determining the Molecular Subtype of Breast Cancer

医学 有效扩散系数 峰度 乳腺癌 直方图 磁共振成像 百分位 相关性 活检 乳房磁振造影 放射科 核医学 癌症 病理 内科学 人工智能 图像(数学) 乳腺摄影术 数学 几何学 统计 计算机科学
作者
Chao You,Yunyan Zhang,Yanqiong Chen,Xiaoxin Hu,HU Dan-ting,Jiong Wu,Yajia Gu,Weijun Peng
出处
期刊:Journal of Computer Assisted Tomography [Lippincott Williams & Wilkins]
卷期号:45 (5): 711-716 被引量:2
标识
DOI:10.1097/rct.0000000000001239
摘要

Rationale and Objectives This study aimed to evaluate the value of background parenchymal enhancement (BPE) and diffusion-weighted image (DWI) histogram features in differentiating among different molecular subtypes of breast cancers and investigate the relationship between BPE and DWI features. Materials and Methods We prospectively enrolled 142 patients with breast cancer between January and November 2018. All patients underwent breast magnetic resonance imaging before core needle biopsy. The quantitative BPE from dynamic enhanced images and the first-order histogram features extracted from DWI were analyzed. Univariate analysis of variance was used to compare differences in DWI histogram features and BPE characteristics among different molecular subtypes. Spearman test was used to compare the correlation between these imaging indexes. Results A total of 142 patients had 142 lesions, including 17 cases of triple-negative breast cancer, 12 cases of luminal A type breast cancer, 39 cases of luminal B type breast cancer, and 74 cases of human epidermal growth factor receptor 2–positive breast cancer. The apparent diffusion coefficient (ADC) 95th percentile, ADC kurtosis, and BPE were significantly different among 4 subtype groups ( P < 0.05), especially between the triple-negative subtype and any other subtype ( P < 0.05 in pairwise comparisons). There was a weak but significant correlation between BPE and kurtosis of ADC ( r = −0.176, P = 0.036). Conclusions Diffusion-weighted image histogram features (95th percentile ADC value and kurtosis value of ADC) and BPE features were different in the 4 molecular subtypes of breast cancer, especially in the triple-negative breast cancer subtype. Background parenchymal enhancement was negatively correlated with the kurtosis value of ADC.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
yong发布了新的文献求助10
1秒前
1秒前
傲娇如天完成签到,获得积分10
1秒前
1秒前
安河桥发布了新的文献求助10
1秒前
张宇驳回了大个应助
2秒前
杨仔发布了新的文献求助10
2秒前
周三完成签到,获得积分10
2秒前
LIUjun发布了新的文献求助10
2秒前
超级千青发布了新的文献求助10
2秒前
chenchen978发布了新的文献求助10
2秒前
天天完成签到 ,获得积分10
3秒前
燕子完成签到,获得积分10
4秒前
重要墨镜完成签到,获得积分10
4秒前
itsdatou完成签到,获得积分10
4秒前
丘比特应助abcd_1067采纳,获得10
5秒前
AA关闭了AA文献求助
5秒前
彭于晏应助单薄的书琴采纳,获得10
5秒前
领导范儿应助自觉的城采纳,获得10
5秒前
HollidayLee完成签到,获得积分10
5秒前
lhnee发布了新的文献求助10
6秒前
雾失楼台完成签到,获得积分10
6秒前
LeePsy完成签到,获得积分10
6秒前
NexusExplorer应助hh采纳,获得10
7秒前
7秒前
orixero应助沉迷学术采纳,获得10
7秒前
下周末发布了新的文献求助10
8秒前
小肥吴完成签到,获得积分10
9秒前
9秒前
cun完成签到,获得积分10
9秒前
QT完成签到,获得积分10
9秒前
yangyangyang完成签到,获得积分10
9秒前
可爱多完成签到,获得积分10
9秒前
宝宝言兼完成签到,获得积分10
9秒前
共享精神应助煎饼果子采纳,获得10
10秒前
精明的橘子完成签到 ,获得积分10
10秒前
11秒前
DUAN完成签到,获得积分10
11秒前
11秒前
栀夏完成签到,获得积分10
12秒前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
Cognitive Neuroscience: The Biology of the Mind 1000
Technical Brochure TB 814: LPIT applications in HV gas insulated switchgear 1000
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
Picture Books with Same-sex Parented Families: Unintentional Censorship 500
Nucleophilic substitution in azasydnone-modified dinitroanisoles 500
不知道标题是什么 500
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3969033
求助须知:如何正确求助?哪些是违规求助? 3513900
关于积分的说明 11170818
捐赠科研通 3249256
什么是DOI,文献DOI怎么找? 1794708
邀请新用户注册赠送积分活动 875326
科研通“疑难数据库(出版商)”最低求助积分说明 804759