餐后
荟萃分析
医学
科克伦图书馆
2型糖尿病
背景(考古学)
随机对照试验
糖尿病
内科学
梅德林
人口
内分泌学
生物
环境卫生
生物化学
古生物学
作者
Kate Vaughan,Viren Ranawana,David Cooper,Magaly Aceves‐Martins
出处
期刊:Nutrition Reviews
[Oxford University Press]
日期:2021-09-21
卷期号:80 (5): 1194-1205
被引量:6
标识
DOI:10.1093/nutrit/nuab069
摘要
Sustained hyperglycemia triggers chronic disease, including type 2 diabetes. A considerable volume of research has explored the effects of brown seaweed on plasma glucose control, but equivocal findings have been reported.A systematic review and meta-analysis was conducted to assess the evidence from human randomized controlled trials (RCTs) on the effects of brown seaweed on plasma glucose in healthy, at-risk, and individuals with type 2 diabetes.MEDLINE/PubMed, EMBASE, and the Cochrane Library were searched for reports published between 2000 and 2020.Population, intervention, comparator, outcome, and study design data were extracted.Eighteen RCTs met our inclusion criteria. The reported results varied across and between populations. Meta-analyses showed a significant effect, favoring the intervention group for both fasting (mean difference -4.6 [95% CI -7.88, -1.33]) and postprandial (mean difference -7.1 [95% CI -7.4, -6.9]) plasma glucose.Brown seaweed and its extracts show potential for preventing and managing hyperglycemia. Our meta-analysis confirms that brown seaweed positively affects plasma glucose homeostasis, with particularly promising postprandial plasma glucose effects. However, further research is needed because no high-quality RCT was identified. Species-specific and dose-response research is also required.PROSPERO registration no. CRD42020187849.
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