Efficacy and Safety of 177Lu-DOTATATE in Lung Neuroendocrine Tumors: A Bicenter study

医学 不良事件通用术语标准 神经内分泌肿瘤 实体瘤疗效评价标准 内科学 不利影响 生长抑素受体 一致性 回顾性队列研究 核医学 胃肠病学 生长抑素 化疗 进行性疾病
作者
Lamiaa Zidan,Amir Iravani,Kira Oleinikov,Simona Ben‐Haim,David J. Gross,Amichay Meirovitz,Ophra Maimon,Tim Akhurst,Michael Michael,Rodney J. Hicks,Simona Grozinsky‐Glasberg,Grace Kong
出处
期刊:The Journal of Nuclear Medicine [Society of Nuclear Medicine]
卷期号:63 (2): 218-225 被引量:29
标识
DOI:10.2967/jnumed.120.260760
摘要

To assess the efficacy and safety of 177Lu-DOTATATE in patients with somatostatin receptor (SSR) positive lung neuroendocrine tumor (NET). Methods: This is a retrospective review of the outcome of patients with typical carcinoid (TC) and atypical carcinoid (AC), treated with 177Lu-DOTATATE at two ENETS Centres of Excellence. Morphological imaging (RECIST 1.1) and 68Ga-DOTATATE PET/CT responses were assessed at 3 months after completion of 177Lu-DOTATATE. Concordance between two response assessment methods was evaluated by Kappa statistics. Progression-free survival (PFS) and overall survival (OS) was estimated by Kaplan-Meier analysis and compared by Log-rank test. Treatment-related adverse events (AEs) were graded based on CTCAE version 5. Results: Of 48 patients (median age, 63 years, 13 female), 43 (90%) had AC and 5 (10%) TC. Almost all patients (47, 98%) were treated due to progression. Majority (40, 83%) received somatostatin analogs and 10 patients (20%) had prior everolimus, chemotherapy or both. All patients had high SSR expression (≥ modified Krenning score 3) on pre-treatment 68Ga-DOTATATE PET/CT. Patients received a median 4 (range 1-4) cycles of 177Lu-DOTATATE (33% with concurrent radiosensitizing chemotherapy) to a median cumulative activity of 27GBq (range 6-43GBq). At median follow-up of 42 months, the median PFS and OS were 23 months (95% CI 18-28 months) and 59 months (95% CI 50-not reached [NR]), respectively. Of 40 patients with RECIST-measurable disease and 39 patients with available 68Ga-DOTATATE PET/CT response categories were: partial response, 20% (95% CI 10-35%) and 44% (95% CI 30-59%); stable disease, 68% (95% CI 52-80%) and 44% (95% CI 30-59%) and progressive disease 12% (95% CI 5-27%) by both, respectively. There was a moderate concordance between response categories by RECIST and 68Ga-DOTATATE PET/CT, weighted Kappa of 0.51 (95% CI 0.21-0.68). Of patients with stable disease by RECIST, those with partial response on 68Ga-DOTATATE PET/CT had longer OS compared to those with no response, NR vs 52 months (95% CI 28-64), HR 0.2 (95% CI 0.1-0.6), p 0.001. Most grade 3/4 AEs were reversible and the most common was lymphopenia (14%) with no incidence of myelodysplasia/leukemia. Conclusion: In patients with advanced progressive lung NET and satisfactory SSR expression, 177Lu-DOTATATE is effective and safe with a high disease control rate and encouraging PFS and OS.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
文心同学完成签到,获得积分10
刚刚
weijian完成签到 ,获得积分10
5秒前
蕉鲁诺蕉巴纳完成签到,获得积分0
5秒前
12秒前
不可靠月亮完成签到,获得积分10
14秒前
Ava应助冷傲凝琴采纳,获得10
14秒前
Zhai发布了新的文献求助10
17秒前
晨珂完成签到,获得积分10
21秒前
23秒前
冷傲凝琴发布了新的文献求助10
27秒前
Keyuuu30完成签到,获得积分0
27秒前
后陡门的夏天完成签到 ,获得积分10
27秒前
人类繁殖学完成签到 ,获得积分10
30秒前
可靠月亮完成签到,获得积分10
34秒前
ArkZ完成签到 ,获得积分10
36秒前
38秒前
等待的靖雁完成签到 ,获得积分20
43秒前
chenkj完成签到,获得积分10
45秒前
EricSai完成签到,获得积分10
46秒前
ikun完成签到,获得积分10
46秒前
虚幻元风完成签到 ,获得积分10
51秒前
gjx完成签到 ,获得积分10
55秒前
肥瑞完成签到 ,获得积分20
56秒前
652183758完成签到 ,获得积分10
58秒前
ycd完成签到,获得积分10
1分钟前
大尧子完成签到 ,获得积分10
1分钟前
雨魂完成签到 ,获得积分10
1分钟前
冷傲凝琴完成签到,获得积分10
1分钟前
const完成签到,获得积分10
1分钟前
文静的电灯胆完成签到,获得积分10
1分钟前
JJ完成签到,获得积分10
1分钟前
tfsn20完成签到,获得积分0
1分钟前
风信子完成签到,获得积分10
1分钟前
风中的老九完成签到,获得积分10
1分钟前
339564965完成签到,获得积分10
1分钟前
ccc完成签到,获得积分10
1分钟前
Helios完成签到,获得积分10
1分钟前
只想顺利毕业的科研狗完成签到,获得积分10
1分钟前
xueshidaheng完成签到,获得积分10
1分钟前
鹏举瞰冷雨完成签到,获得积分10
1分钟前
高分求助中
Licensing Deals in Pharmaceuticals 2019-2024 3000
Cognitive Paradigms in Knowledge Organisation 2000
Mantiden: Faszinierende Lauerjäger Faszinierende Lauerjäger Heßler, Claudia, Rud 1000
PraxisRatgeber: Mantiden: Faszinierende Lauerjäger 1000
Natural History of Mantodea 螳螂的自然史 1000
A Photographic Guide to Mantis of China 常见螳螂野外识别手册 800
How Maoism Was Made: Reconstructing China, 1949-1965 800
热门求助领域 (近24小时)
化学 医学 材料科学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 量子力学 冶金 电极
热门帖子
关注 科研通微信公众号,转发送积分 3317034
求助须知:如何正确求助?哪些是违规求助? 2948754
关于积分的说明 8542058
捐赠科研通 2624676
什么是DOI,文献DOI怎么找? 1436406
科研通“疑难数据库(出版商)”最低求助积分说明 665891
邀请新用户注册赠送积分活动 651810