The Importance of Natural ACE2 Inhibitor: Potency of Porang (Amorphophallus muelleri) Glucomannan as Anti-SARS-Cov-2

The inhibition of SARS-Cov-2 S binding with hACE2, expressed in most human tissues, may prevent the severity of virus infection. However, commercial ACE2 inhibitor drugs are still limited, while several natural compounds have already been reported to have anti-ACE2 activity. We found the potential of hydrolyzed glucomannan of porang tuber in the inhabitation of binding activity between ACE2 and S1 of SARS-Cov-2.