Intrathecal Production of MOG-IgG

Myelin oligodendrocyte glycoprotein (MOG) antibody (Ab)–associated disease (MOGAD) is now a well-recognized demyelinating disease. Despite the phenotypic overlap with both multiple sclerosis and aquaporin-4 (AQP4)-Ab neuromyelitis optica spectrum disorder, cumulative clinical and immunologic evidence clearly discriminates between these conditions.