Estrogen Receptors and Cell Signaling

The Report by C. M. Revankar et al. (“A transmembrane intracellular estrogen receptor mediates rapid cell signaling,” 11 Mar., p. 1625) presents findings that the G protein-coupled receptor GPR30 localizes exclusively to endoplasmic reticulum and binds an estradiol-Alexa dye conjugate. As such,