PTEN公司
丁酸钠
PI3K/AKT/mTOR通路
磷酸肌醇3激酶
癌症研究
丁酸盐
化学
细胞生长
细胞生物学
激酶
信号转导
生物
生物化学
基因
发酵
作者
Zhigang Bai,Zhongtao Zhang,Yingjiang Ye,Shan Wang
摘要
Abstract NaB (sodium butyrate) inhibits cell proliferation and induces differentiation in a variety of tumour cells. In this study, we aimed to determine whether NaB induced differentiation and regulated the expression of the mucosal factor MUC2 through the PTEN/PI3K (phosphoinositide 3‐kinase) pathway. BGC823 cells treated with NaB for 24–72 h showed marked inhibition of cell proliferation and alteration in cellular morphology. NaB treatment markedly increased the expression of PTEN and MUC2, but it decreased the expression of PI3K. These effects were enhanced by intervention with PI3K inhibitors and were reduced by intervention with PTEN siRNA. Hence, we conclude that NaB increased PTEN expression, promoted the expression of MUC2 and induced the differentiation of gastric cancer cells through the PTEN/PI3K signalling pathway.
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