Nanogel–Calcium Phosphate Hybrid Nanoparticles with Negative or Positive Charges for Potential Biomedical Applications

Abstract Self-assembled polysaccharide nanogels with negative or positive charges were used as templates for mineralization of calcium phosphate for potential biomedical application. The formation of stable and negatively- or positively-charged amorphous calcium phosphate nanoparticles was confirmed by transmission electron microscopy, energy-dispersive X-ray spectroscopy, and ζ-potential measurements.