Short De Novo Synthesis of Fully Functionalized Uronic Acid Monosaccharides

Short and Sweet: A convergent route leads to orthogonally protected D-glucuronic and L-iduronic acid thioglycoside building blocks, commonly used in heparin oligosaccharide assembly (see scheme). Rapid access to substantial quantities of these key intermediates feeds the growing need for monosaccharide building blocks for use in the assembly of bioactive oligosaccharides. PG=protecting group.