脂磷壁酸
生物
表观遗传学
结直肠癌
DNA甲基化
结肠炎
癌症
癌症研究
嗜酸乳杆菌
免疫学
基因
基因表达
遗传学
益生菌
细菌
金黄色葡萄球菌
作者
Yaíma L. Lightfoot,Tao Yang,Bikash Sahay,Mansour Mohamadzadeh
出处
期刊:Gut microbes
[Informa]
日期:2012-11-08
卷期号:4 (1): 84-88
被引量:42
摘要
Pathogenic autoinflammatory responses triggered by dysregulated microbial interactions may lead to intestinal disorders and malignancies. Previously, we demonstrated that a lipoteichoic acid (LTA)-deficient Lactobacillus acidophilus strain, NCK2025, ameliorated inflammation-induced colitis, significantly reduced the number of polyps in a colonic polyposis cancer model and restored physiological homeostasis in both cases. Nonetheless, the regulatory signals delivered by NCK2025 to reprogram the gastrointestinal microenvironment, and thus resist colonic cancer progression, remain unknown. Accumulating evidence suggest that epigenetic changes, in the presence and absence of pathogenic inflammation, can result in colorectal cancer (CRC). To test possible epigenetic modifications induced by NCK2025, the expression of epigenetically regulated, CRC-associated genes was measured with and without bacterial treatment. In vivo and in vitro, NCK2025 enhanced the expression of tumor suppressor genes that may regulate CRC development. Therefore, differential epigenetic regulation of CRC-related genes by NCK2025 represents a potential therapy against colitis-associated and sporadic CRC.
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