Effects of diffusion impairment on O 2 and CO 2 time courses in pulmonary capillaries.

ArticleEffects of diffusion impairment on O 2 and CO 2 time courses in pulmonary capillaries.P D Wagner, and J B WestP D Wagner, and J B WestPublished Online:01 Jul 1972https://doi.org/10.1152/jappl.1972.33.1.62MoreSectionsPDF (2 MB)Download PDF ToolsExport citationAdd to favoritesGet permissionsTrack citations ShareShare onFacebookTwitterLinkedInWeChat Previous Back to Top Next Download PDF FiguresReferencesRelatedInformation Cited ByPreserved peak exercise capacity in Andean highlanders with excessive erythrocytosis both before and after isovolumic hemodilutionCecilia Anza-Ramírez,* Wanjun Gu,* José L. Macarlupú, Rómulo J. Figueroa-Mujíca, Gustavo A. Vizcardo-Galindo, Erica C. Heinrich, Michael S. Tift, Harrieth E. Wagner, Peter D. Wagner, Tatum S. Simonson, and Francisco C. Villafuerte19 December 2022 | Journal of Applied Physiology, Vol. 134, No. 1A century of exercise physiology: key concepts on coupling respiratory oxygen flow to muscle energy demand during exercise26 February 2022 | European Journal of Applied Physiology, Vol. 122, No. 6Pulmonary function tests in systemic sclerosis-associated interstitial lung disease: new directions and future prospectsCurrent Opinion in Physiology, Vol. 22Relating Ventilatory Support and Drug Treatment Strategies to the Fundamental Pathophysiology in COVID-19 Illness1 June 2021 | European Medical JournalOxygen21 February 2020Carbon Dioxide21 February 2020Metabolic Modeling in Altered GravityDifferences in alveolo-capillary equilibration in healthy subjects on facing O2 demand13 November 2019 | Scientific Reports, Vol. 9, No. 1Left Ventricular Assist Device Support Complicates the Exercise Physiology of Oxygen Transport and Uptake in Heart Failure4 November 2019 | Cardiac Failure Review, Vol. 5, No. 3Alveolar Air and O2 Uptake During Exercise in Patients With Heart FailureJournal of Cardiac Failure, Vol. 24, No. 10Use of 'ideal' alveolar air equations and corrected end-tidal PCO2 to estimate arterial PCO2 and physiological dead space during exercise in patients with heart failureInternational Journal of Cardiology, Vol. 250Exercise Stroke Volume in Adult Cystic Fibrosis: A Comparison of Acetylene Pulmonary Uptake and Oxygen Pulse25 July 2018 | Clinical Medicine Insights: Circulatory, Respiratory and Pulmonary Medicine, Vol. 12The physiology of submaximal exercise: The steady state conceptRespiratory Physiology & Neurobiology, Vol. 246The impact of spontaneous ventilation on non-operative lung injury in thoracic surgery: a randomized controlled rabbit model study3 July 2017 | European Journal of Cardio-Thoracic Surgery, Vol. 52, No. 6Effects of erythropoietin on systemic hematocrit and oxygen transport in the splenectomized horseRespiratory Physiology & Neurobiology, Vol. 225Ventilation, Blood Flow, and Gas ExchangeA re-analysis of the 1968 Saltin et al. "Bedrest" paper19 November 2015 | Scandinavian Journal of Medicine & Science in Sports, Vol. 25Low haemoglobin concentration in Tibetan males is associated with greater high-altitude exercise capacity25 June 2015 | The Journal of Physiology, Vol. 593, No. 14Intrapulmonary arteriovenous anastomoses in humans - response to exercise and the environment7 January 2015 | The Journal of Physiology, Vol. 593, No. 3Gas Exchange at Rest and during Exercise in MammalsThe physiological basis of pulmonary gas exchange: implications for clinical interpretation of arterial blood gases16 October 2014 | European Respiratory Journal, Vol. 45, No. 1Aerobic Metabolism and the Steady-State Concept26 March 2015Increased blood-oxygen binding affinity in Tibetan and Han Chinese residents at 4200 m1 December 2014 | Experimental Physiology, Vol. 99, No. 12Increased cardiac output, not pulmonary artery systolic pressure, increases intrapulmonary shunt in healthy humans breathing room air and 40% O 23 September 2014 | The Journal of Physiology, Vol. 592, No. 20Lack of functional information explains the poor performance of 'clot load scores' at predicting outcome in acute pulmonary embolismRespiratory Physiology & Neurobiology, Vol. 190Precapillary Oxygenation Contributes Relevantly to Gas Exchange in the Intact LungAmerican Journal of Respiratory and Critical Care Medicine, Vol. 188, No. 4Automated measurement of blood flow velocity and direction and hemoglobin oxygen saturation in the rat lung using intravital microscopyGabi Hanna, Andrew Fontanella, Gregory Palmer, Siqing Shan, Daniel R. Radiloff, Yulin Zhao, David Irwin, Karyn Hamilton, Alina Boico, Claude A. Piantadosi, Gert Blueschke, Mark Dewhirst, Timothy McMahon, and Thies Schroeder15 January 2013 | American Journal of Physiology-Lung Cellular and Molecular Physiology, Vol. 304, No. 2Study of arterial blood gas changes in patients undergoing abdominal hernia repair surgery29 September 2012 | Hellenic Journal of Surgery, Vol. 84, No. 4Respiratory Physiology and CareEvidence for minimal oxygen heterogeneity in the healthy human pulmonary acinusAnnalisa J. Swan, and Merryn H. Tawhai1 February 2011 | Journal of Applied Physiology, Vol. 110, No. 2Exercise: Kinetic Considerations for Gas Exchange1 November 2010Ventilation, Blood Flow, and Gas ExchangeDisequilibrium Between Alveolar and End-Pulmonary-Capillary O2 Tension in Altitude Hypoxia and Respiratory Disease: An Update of a Mathematical Model of Human Respiration at Altitude1 July 2009 | Annals of Biomedical Engineering, Vol. 37, No. 9GAS EXCHANGE IN THE LUNGSHemoglobin P 50 during A Simulated Ascent of Mt. Everest, Operation Everest IIHigh Altitude Medicine & Biology, Vol. 8, No. 1Multiscale model for pulmonary oxygen uptake and its application to quantify hypoxemia in hepatopulmonary syndromeJournal of Theoretical Biology, Vol. 244, No. 2Respiratory Physiology and CareA simulation model of the oxygen alveolo capillary exchange in normal and pathological conditions28 February 2003 | Physiological Measurement, Vol. 24, No. 2Voltage-Gated Proton Channels and Other Proton Transfer PathwaysThomas E. Decoursey1 April 2003 | Physiological Reviews, Vol. 83, No. 2Pulmonary gas exchange and acid-base state at 5,260 m in high-altitude Bolivians and acclimatized lowlandersPeter D. Wagner, Mauricio Araoz, Robert Boushel, José A. L. Calbet, Birgitte Jessen, Göran Rådegran, Hilde Spielvogel, Hans Søndegaard, Harrieth Wagner, and Bengt Saltin1 April 2002 | Journal of Applied Physiology, Vol. 92, No. 4Hypoxic HypoxiaModels of Tissue Oxygen Uptake and Microcirculatory Blood Flow27 June 2013Effect of cardiac output on pulmonary gas exchange: role of diffusion limitation with V̇a/Q̇ mismatchRespiration Physiology, Vol. 113, No. 1Determinants of Gas Exchange and Acid–Base Balance During Exercise1 January 2011Na + -independent Active H + Extrusion and HCO 3− /C1 − Exchange Contribute to Cytoplasmic pH Regulation in the Human Platelet7 July 2009 | Platelets, Vol. 6, No. 4Ventilatory FailureAcid—Base Status and Blood Lactate at Extreme AltitudeTransition from Exercise to RestChest, Vol. 99, No. 5Effect of the curvature of the O2 equilibrium curve on alveolar O2 uptake: theoryRespiration Physiology, Vol. 83, No. 3Respiratory Gas FlowDistribution of Ventilation and Diffusion with Perfusion in a Two-Compartment Model of Gas ExchangeModeling of Gas Exchange in Lungs, Gills and SkinKinetics of Oxygen and Carbon Dioxide ExchangeEstimating steady-state DlO2 with nonlinear dissociation curves and Va/Q̇ inequalityRespiration Physiology, Vol. 73, No. 3Diffusion of Gases Across the Alveolar Membrane1 January 2011Carbon Dioxide Transport1 January 2011The effect of blood flow and diffusion impairment on pulmonary gas exchange: A computer modelComputers and Biomedical Research, Vol. 20, No. 5A numerical study of the nonsteady transport of gases in the pulmonary capillariesJournal of Mathematical Biology, Vol. 25, No. 4Oxygen diffusing capacity estimates derived from measured V̇A/Q̇ distributions in manRespiration Physiology, Vol. 69, No. 2The rate of oxygen release and its effect on capillary O2 tension: A mathematical analysisRespiration Physiology, Vol. 63, No. 1A model for red cell O2 uptakeInternational Journal of Clinical Monitoring and Computing, Vol. 2, No. 2Computer Applications in Pulmonary Function TestingAtmungChanges in transcutaneous oxygen tension during exercise in pulmonary emphysema.Thorax, Vol. 39, No. 6Acute Pulmonary EdemaCardiology Clinics, Vol. 2, No. 2Climbing Mt. Everest without oxygen: An analysis of maximal exercise during extreme hypoxiaRespiration Physiology, Vol. 52, No. 3Respiratory Failure, Mechanisms of Abnormal Gas Exchange, and Oxygen DeliveryMedical Clinics of North America, Vol. 67, No. 3The Influence of Cardiovascular Function on Gas ExchangeClinics in Chest Medicine, Vol. 4, No. 2FACILITATED TRANSPORT OF CARBON DIOXIDE: A REVIEW20 January 2011 | Chemical Engineering Communications, Vol. 16, No. 1-6Influence of mixed venous P O2 on diffusion of O 2 across the pulmonary blood: gas barrierClinical Physiology, Vol. 2, No. 24. What does the transfer of carbon monoxide mean?British Journal of Diseases of the Chest, Vol. 76Alveolar-arterial PCO2 differences and diffusion limitationLung, Vol. 159, No. 1Model for capillary-alveolar equilibration with special reference to O2 uptake in hypoxiaRespiration Physiology, Vol. 46, No. 3ROLE OF DIFFUSION IMPAIRMENT IN GAS EXCHANGEThe Myogenic Response1 January 2011Predicted gas exchange on the summit of Mt. EverestRespiration Physiology, Vol. 42, No. 1Alveolar-capillary equilibration kinetics of 13CO2 in human lungs studied by rebreathingRespiration Physiology, Vol. 42, No. 1Pulmonary O 2 transfer during pulsatile and non-pulsatile perfusionActa Physiologica Scandinavica, Vol. 109, No. 3Blood–Gas Equilibration in LungsKinetics of Pulmonary Gas ExchangeNumerical Analysis of Gas ExchangeVenous admixture in human septic shock: comparative effects of blood volume expansion, dopamine infusion and isoproterenol infusion on mismatching of ventilation and pulmonary blood flow in peritonitis.Circulation, Vol. 60, No. 1Der Einfluß des Beatmungsmusters auf Gasaustausch und LungenmechanikA quantitative analysis of CO2 transport at rest and during maximal exerciseRespiration Physiology, Vol. 35, No. 2Analysis of the effects of pulsatile capillary blood flow and volume on gas exchangeRespiration Physiology, Vol. 35, No. 1THE BLOOD OXYGEN TRANSPORT SYSTEM A numerical simulation of capillary-tissue respiratory gas exchange24 April 2009 | Acta Medica Scandinavica, Vol. 197, No. S578Effect of plasma proteins on oxygen diffusion in the pulmonary capillariesMicrovascular Research, Vol. 7, No. 1Measurement of the Gas-Exchanging Function of the Lung1 September 2016 | Proceedings of the Royal Society of Medicine, Vol. 66, No. 10Effect of acceleration on distribution of lung perfusion and on respiratory gas exchangePflügers Archiv, Vol. 342, No. 2 More from this issue > Volume 33Issue 1July 1972Pages 62-71 https://doi.org/10.1152/jappl.1972.33.1.62PubMed5037412History Published online 1 July 1972 Published in print 1 July 1972 Metrics