细胞生物学
GTP酶
圆周率
激酶
第二信使系统
信号转导
肌动蛋白细胞骨架
细胞骨架
生物
化学
生物化学
细胞
作者
Trevor Jackson,Brian G. Kearns,Anne B. Theibert
标识
DOI:10.1016/s0968-0004(00)01644-3
摘要
Abstract
Receptor-activated phosphoinositide (PI) 3-kinases produce PtdIns(3,4,5)P3 and its metabolite PtdIns(3,4)P2 that function as second messengers in membrane recruitment and activation of target proteins. The cytohesin and centaurin protein families are potential targets for PtdIns(3,4,5)P3 that also regulate and interact with Arf GTPases. Consequently, these families are poised to transduce PI 3-kinase activation into coordinated control of Arf-dependent pathways. Proposed downstream events in PI 3-kinase-regulated Arf cascades include modulation of vesicular trafficking and the actin cytoskeleton.
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