Ronny Priefer,Justin R. Griffiths,Janelle N. Ludwig,Graham Skelhorne‐Gross,Robert S. Greene
出处
期刊:Letters in Organic Chemistry [Bentham Science] 日期:2011-06-13卷期号:8 (6): 368-373被引量:10
标识
DOI:10.2174/157017811796064377
摘要
BF2 Chelated azadipyrromethene dyes fluoresce in the near infrared and have potential applications in photodynamic therapy. When irradiated above 600nm these aza-BODIPY compounds react with triplet O2 in the body to form a reactive singlet oxygen species which leads to cell death. A small library has been synthesized of these potential PDT agents via a four step process, with varying substituents on the aromatic ring of the starting benzaldehyde and acetophenone. In vitro studies on HeLa cells have revealed an effective photosensitive compound with low dark cytotoxicity and promotion of apoptotic cell death when exposed to light.