巨噬细胞极化
免疫系统
炎症
代谢途径
糖酵解
柠檬酸循环
表型
细胞生物学
巨噬细胞
重编程
先天免疫系统
生物
新陈代谢
免疫学
生物化学
细胞
基因
体外
作者
Meiyun Liu,Pengcheng Zhang,Xin Lyu
出处
期刊:PubMed
日期:2020-06-01
卷期号:32 (6): 765-768
被引量:6
标识
DOI:10.3760/cma.j.cn121430-20200211-00177
摘要
Macrophages are important innate immune cells that play essential roles in the inflammatory response. The phenotypic plasticity of macrophages enables them to be polarized into distinct gene phenotypes under different immune microenvironments to regulate the process of inflammation. The study of macrophage metabolic reprogramming aims to clarify the influence of key metabolic pathways on the regulation of different polarization states and related functions of macrophages. This review focuses on the relationship between the four key metabolic pathways [glycolysis, tricarboxylic acid (TCA) cycle, fatty acid metabolism and amino acid metabolism] and the distinct gene phenotypes of macrophages. It also reveals the metabolic regulation of the immune function of macrophage cells thus to provide new ideas and methods for the study of macrophage polarization-related process of inflammation.
科研通智能强力驱动
Strongly Powered by AbleSci AI