脂肪因子
非酒精性脂肪肝
脂肪组织
平衡
脂肪肝
脂质代谢
炎症
胰岛素抵抗
医学
非酒精性脂肪性肝炎
肥胖
肝病
内科学
疾病
内分泌学
作者
Vian Azzu,Michèle Vacca,Sam Virtue,Michael Allison,Antonio Vidal–Puig
标识
DOI:10.1053/j.gastro.2019.12.054
摘要
Adipose tissue and the liver play significant roles in the regulation of whole-body energy homeostasis, but they have not evolved to cope with the continuous, chronic, nutrient surplus seen in obesity. In this review, we detail how prolonged metabolic stress leads to adipose tissue dysfunction, inflammation, and adipokine release that results in increased lipid flux to the liver. Overall, the upshot of hepatic fat accumulation alongside an insulin-resistant state is that hepatic lipid enzymatic pathways are modulated and overwhelmed, resulting in the selective buildup of toxic lipid species, which worsens the pro-inflammatory and pro-fibrotic shift observed in nonalcoholic steatohepatitis.
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