Novel scheme for non-invasive gut bioinformation acquisition with a magnetically controlled sampling capsule endoscope

代谢组 生物 微生物群 代谢组学 肠道菌群 抗生素 病理 志贺氏菌 胃肠病学 医学 生物信息学 免疫学 微生物学 细菌 遗传学 沙门氏菌
作者
Zhen Ding,Weijun Wang,Kun Zhang,Fanhua Ming,Tianyi Yangdai,Tao Xu,Huiying Shi,Yuhui Bao,Hailing Yao,Hangyu Peng,Chaoqun Han,Weiwei Jiang,Jun Liu,Xiaohua Hou,Rong Lin
出处
期刊:Gut [BMJ]
卷期号:70 (12): 2297-2306 被引量:37
标识
DOI:10.1136/gutjnl-2020-322465
摘要

Objective Intestinal flora and metabolites are associated with multiple systemic diseases. Current approaches for acquiring information regarding microbiota/metabolites have limitations. We aimed to develop a precise magnetically controlled sampling capsule endoscope (MSCE) for the convenient, non-invasive and accurate acquisition of digestive bioinformation for disease diagnosis and evaluation. Design The MSCE and surgery were both used for sampling both jejunal and ileal GI content in the control and antibiotic-induced diarrhoea groups. The GI content was then used for microbiome profiling and metabolomics profiling. Results Compared with surgery, our data showed that the MSCE precisely acquired data regarding the intestinal flora and metabolites, which was effectively differentiated in different intestinal regions and disease models. Using MSCE, we detected a dramatic decrease in the abundance of Bacteroidetes, Patescibacteria and Actinobacteria and hippuric acid levels, as well as an increase in the abundance of Escherichia–Shigella and the 2-pyrrolidinone levels were detected in the antibiotic-induced diarrhoea model by MSCE. MSCE-mediated sampling revealed specific gut microbiota/metabolites including Enterococcus , Lachnospiraceae , acetyl-L-carnitine and succinic acid, which are related to metabolic diseases, cancers and nervous system disorders. Additionally, the MSCE exhibited good sealing characteristics with no contamination after sampling. Conclusions We present a newly developed MSCE that can non-invasively and accurately acquire intestinal bioinformation via direct visualization under magnetic control, which may further aid in disease prevention, diagnosis, prognosis and treatment.
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