Effect of laparoscopic sleeve gastrectomy on obesity and type 2 diabetes mellitus

Objective To explore the morbidity of surgery in connection with laparoscopic sleeve gastrectomy (LSG) and its effect on obese T2DM. Methods 106 obese T2DM patientes undergoing LSG were divided into 2 groups in group 1 25 patients did not have oversewing the staple line and group 2 81 patients had the staple line oversewn in order to reduce bleeding. Results The differences in intraoperative blood loss (35±15) ml vs. (28±18)ml, postoperative recovery time (2.4±0.9)d vs. (2.3±0.9)d, time to taking liquid food (4.7±1.0)d vs. (4.6±1.0)d between two groups were not significant. There were no significant difference of complication between 2 groups (χ2=3.271, P=0.071). Comparing before surgery to 6 month after surgery, the BMI in group 1, was from (39±5) to (29±4) kg/m2; in group 2, from (40±6) to (31±5) kg/m2, FPG in group 1, from (8.4±1.4) to (6.4±1.2) mmol/L; in group 2, from (8.2±2.0) to (6.8±1.5) mmol/L, 2 hour post-meal blood sugar [group 1, (13.2±4.1) to (9.6±3.2) mmol/L; group 2, (12.2±3.2) to (10.6±2.8) mmol/L] and HbA1c (group 1, 7.2%±1.2% to 5.5%±1.1%; group 2, 7.1%±1.1% to 5.9%±1.2%) decreased significantly in both groups (P<0.01). There was 72 (68%) remission cases of T2DM in 106 patients, there were no significant differences of T2DM remission and BMI between 2 groups at 6 months after surgery (P=0.617). Conclusions LSG leads to significant weight loss and T2DM control. Key words: Diabetes mellitus, type 2; Gastrectomy; Postoperative complications