氧化应激
线粒体
疾病
细胞生物学
心脏病学
生物
氧化磷酸化
内科学
医学
生物化学
作者
Jessica N. Peoples,Anita Saraf,Nasab Ghazal,Tyler T. Pham,Jennifer Q. Kwong
标识
DOI:10.1038/s12276-019-0355-7
摘要
Abstract Beyond their role as a cellular powerhouse, mitochondria are emerging as integral players in molecular signaling and cell fate determination through reactive oxygen species (ROS). While ROS production has historically been portrayed as an unregulated process driving oxidative stress and disease pathology, contemporary studies reveal that ROS also facilitate normal physiology. Mitochondria are especially abundant in cardiac tissue; hence, mitochondrial dysregulation and ROS production are thought to contribute significantly to cardiac pathology. Moreover, there is growing appreciation that medical therapies designed to mediate mitochondrial ROS production can be important strategies to ameliorate cardiac disease. In this review, we highlight evidence from animal models that illustrates the strong connections between mitochondrial ROS and cardiac disease, discuss advancements in the development of mitochondria-targeted antioxidant therapies, and identify challenges faced in bringing such therapies into the clinic.
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