Ternary choline chloride/caffeic acid/ethylene glycol deep eutectic solvent as both a monomer and template in a molecularly imprinted polymer

Journal of Separation ScienceVolume 40, Issue 10 p. 2286-2291 SHORT COMMUNICATION Ternary choline chloride/caffeic acid/ethylene glycol deep eutectic solvent as both a monomer and template in a molecularly imprinted polymer Najing Fu, Najing Fu College of Pharmaceutical Science, Hebei University, Baoding, ChinaSearch for more papers by this authorXiao Liu, Xiao Liu College of Pharmaceutical Science, Hebei University, Baoding, ChinaSearch for more papers by this authorLiteng Li, Liteng Li College of Pharmaceutical Science, Hebei University, Baoding, ChinaSearch for more papers by this authorBaokun Tang, Corresponding Author Baokun Tang tangbaokun@hbu.edu.cn orcid.org/0000-0001-8679-972X College of Pharmaceutical Science, Hebei University, Baoding, China Correspondence Dr Baokun Tang, College of Pharmaceutical Science, Hebei University, Baoding 071002, China. Email: tangbaokun@hbu.edu.cn; tangbaokun01@163.comSearch for more papers by this authorKyung Ho Row, Kyung Ho Row Department of Chemistry and Chemical Engineering, Inha University, Incheon, Korea Additional corresponding author Professor Kyung Ho Row Email: rowkho@inha.ac.krSearch for more papers by this author Najing Fu, Najing Fu College of Pharmaceutical Science, Hebei University, Baoding, ChinaSearch for more papers by this authorXiao Liu, Xiao Liu College of Pharmaceutical Science, Hebei University, Baoding, ChinaSearch for more papers by this authorLiteng Li, Liteng Li College of Pharmaceutical Science, Hebei University, Baoding, ChinaSearch for more papers by this authorBaokun Tang, Corresponding Author Baokun Tang tangbaokun@hbu.edu.cn orcid.org/0000-0001-8679-972X College of Pharmaceutical Science, Hebei University, Baoding, China Correspondence Dr Baokun Tang, College of Pharmaceutical Science, Hebei University, Baoding 071002, China. Email: tangbaokun@hbu.edu.cn; tangbaokun01@163.comSearch for more papers by this authorKyung Ho Row, Kyung Ho Row Department of Chemistry and Chemical Engineering, Inha University, Incheon, Korea Additional corresponding author Professor Kyung Ho Row Email: rowkho@inha.ac.krSearch for more papers by this author First published: 28 March 2017 https://doi.org/10.1002/jssc.201700146Citations: 24 Conflict of interest: The authors have declared no conflict of interest. Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat Abstract A molecularly imprinted polymer based on a ternary deep eutectic solvent comprised of choline chloride/caffeic acid/ethylene glycol was prepared. The caffeic acid in the ternary deep eutectic solvent was used as both a monomer and template. The molecularly imprinted polymer based on the ternary deep eutectic solvent was characterized by Fourier transform infrared spectroscopy, thermogravimetric analysis, field-emission scanning electron microscopy, Brunauer–Emmett–Teller surface area analysis, atomic force microscopy, and elemental analysis. A series of molecularly imprinted polymers based on choline chloride/caffeic acid/ethylene glycol with different molar ratios was prepared and applied to the molecular recognition of polyphenols. A comparison of the recognition ability of molecularly imprinted polymers to polyphenols revealed that the choline chloride/caffeic acid/ethylene glycol (1:0.4:1, molar ratio) molecularly imprinted polymer had the best molecular recognition effect with 132 μg/g of protocatechuic acid, 104 μg/g of catechins, 80 μg/g of epicatechin, and 123 μg/g of caffeic acid in 6 h, as well as good molecular recognition ability for polyphenols from a Radix Asteris sample. These results show that the ternary deep eutectic solvent based molecularly imprinted polymer is a potential medium that can be applied to drug purification, drug delivery, and drug analysis. Citing Literature Volume40, Issue10May 2017Pages 2286-2291 RelatedInformation