化学
阿布茨
DPPH
抗氧化剂
消炎药
一氧化氮
木脂素
传统医学
生物化学
立体化学
药理学
有机化学
医学
作者
Ying Peng,Li‐Li Lou,Sifan Liu,Le Zhou,Xiao‐Xiao Huang,Shao‐Jiang Song
标识
DOI:10.1016/j.bmcl.2016.10.012
摘要
Seven new neolignans (1-2, 7-11) and five known compounds (3-6, 12) were isolated from the 70% EtOH extract of hawthorn seeds. Their structures were determined by spectroscopic analyses. The antioxidant and anti-inflammatory activities of all the isolates were investigated. Most of the isolates showed moderate radical scavenging activity in the DPPH assay and significant activities in the ABTS and FRAP assays. Furthermore, compounds 7-12 exhibited marked nitric oxide (NO) inhibition and compounds 1-4 had a potent necrosis factor-α (TNF-α) inhibitory effect. The results we obtained showed that hawthorn seeds can be regarded as a potential new and cheap source of antioxidants and inflammation inhibitors.
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