根茎
萎缩
咖啡酸
化学
生物
神经科学
生物化学
植物
医学
病理
抗氧化剂
作者
Zhiyou Yang,Tomoharu Kuboyama,Kohei Kazuma,Katsuhiro Konno,Chihiro Tohda
标识
DOI:10.1021/acs.jnatprod.5b00290
摘要
Axonal regeneration might contribute to the restoration of damaged neuronal networks and improvement of memory deficits in a murine Alzheimer's disease (AD) model. A search for axonal regenerative drugs was performed to discover novel therapeutic options for AD. In this study, an aqueous extract of Drynaria fortunei rhizomes reversed Aβ25–35-induced axonal atrophy in cultured cortical neurons of mice. Bioassay-guided fractionation of this extract led to the isolation and identification of compounds 1–5. Among them, (2S)-neoeriocitrin (2) and caffeic acid 4-O-glucoside (4) showed significant axonal elongation effects on Aβ25–35-induced atrophy.
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