聚合酶
核糖核酸
抄写(语言学)
RNA聚合酶
生物
核酸
细胞生物学
计算生物学
化学
遗传学
DNA
基因
语言学
哲学
作者
Dina Grohmann,Angela Hirtreiter,Finn Werner
出处
期刊:Biochemical Society Transactions
[Portland Press]
日期:2009-01-20
卷期号:37 (1): 12-17
被引量:14
摘要
All cellular life depends on multisubunit RNAPs (RNA polymerases) that are evolutionarily related through the three domains of life. Archaeal RNAPs encompass 12 subunits that contribute in different ways to the assembly and stability of the enzyme, nucleic acid binding, catalysis and specific regulatory interactions with transcription factors. The recent development of methods to reconstitute archaeal RNAP from recombinant materials in conjunction with structural information of multisubunit RNAPs present a potent opportunity to investigate the molecular mechanisms of transcription.
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